Sarah Kirkwood shot a team-low 41 to lead four players in the 40s, helping Santa Barbara High to a 227, its lowest score of the year.
But Oxnard, playing on its home course at River Ridge Golf Club, fired a 216 to beat the Dons for the second time this season.
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Haley True carded the second lowest score for the Dons at 44, followed by 46s from Saralisa Ortega and Olivia Fanaro. Alissa Crane rounded out the score with a 50.
The Dons are at Spanish Hills Country Club Tuesday for a match against Rio Mesa.